Mike Huckabee -- with a bit of dodging -- refused to recant his 1992 comments that we should "isolate" AIDS patients. Notably, by 1992 it was well established that AIDS was not transmitted through casual contact. But AIDS still carried with it an unbelievable amount of stigma, and Huckabee was playing into that. I have to admit that I am surprised he didn't repudiate those words though. It seemed like a no-brainer.
This seems to me to be the grand Huckabee paradox. He does have a lot of personal charm and charisma. To counteract that, he has a lot of positions that are -- bluntly -- crazy. This can be a winning combination (it won in 2000 and 2004), but unlike its current poster boy, Huckabee seems to lack the instincts of a true politician. He doesn't know when and how to spin, when to hold the line and when to break. In this, he's a bit refreshing, actually. But it's a flaw as a candidate, and if it prevents someone with his retrograde views on all manner of issues from taking office, so much the better.