Right now, the prevailing thrust of the Republican plan to rescue itself from irrelevancy is that they need to become even more purer. Sen. Jim DeMint (R-SC) expressed the agenda in particularly inane fashion by saying "our plan is freedom" (after declaring he'd prefer 30 Senators "with principles" than 60 "who had none"), and declaring that "The federal government is too big, takes too much of our money, and makes too many of our decisions." Though objectively speaking neither DeMint nor other orthodox Republicans have the slightest interest in reducing government (ask your local woman or gay person for their thoughts on the matter), even interpreting it charitably -- that is, a strategy centered around less government spending, a reduced safety net, and economic intervention, it looks like -- surprise -- it's still a loser.
That's the response rate for the under-30 crowd -- the very demographic group that will rule American politics in the future, as well as the one voted "most likely to hate the GOP with the fury of a thousands suns". As Yglesias notes, typically the emergent Republican problem with younger voters is cast in terms of social differences (they loathe gay people, we don't). But it seems to be that the chasm is much broader than that, and represents a wholesale repudiation of Republican ideology up and down the political map.